From its inception, the U.S. Department of Veterans Affairs has deemed research an essential component to meet its mission: to provide the highest quality of health care possible to those who have served our country. Since 1946, clinical trials have been conducted at the VA that focus on alleviating the conditions prevalent among veterans. The goal of these trials has been to offer new drugs, devices and techniques to veterans to improve their health.
The principal investigators (PI) affiliated with the CRF are VA physicians who are committed to providing excellent care to their patients. Excellent care starts with an informed patient. Though you may receive many benefits from participating in clinical research as a subject–from gaining access to the latest pharmaceutical developments to the empowering feeling of giving back–there can be some risks, so if you are considering the possibility of participating please take time to evaluate for yourself and with your doctor if doing so is an appropriate option.
NOW ENROLLING! Open Clinical Trials:
CONDITIONS
STUDY NAME
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CONTACT
Cardiovascular Disease
Veterans Affairs (VA) Lipid Optimization Reimagined (VALOR-QI) in Veterans with Atherosclerotic Cardiovascular Disease (ASCVD) VA Multisite Project (VALOR–QI)
Anne Marie Webb
502-287-5238
Colorectal Neoplasia
Artificial Intelligence for the Management of Colorectal Neoplasia using combined-modality Spectroscopy and Enhanced Imaging – A Multi-Site Study
Anne Marie Webb
502-287-5238
Cognitive Impairment
Cardiovascular Disease
Dementia
PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
Jordan Ricks
502-287-5208
Liver
Liver and Systemic Effects of Toxic Exposures
Jordan Ricks
502-287-5208
Colorectal Cancer
Evaluation of ctDNA LUNAR-2 Assay in an Average Patient Screening Episode (ECLIPSE)
Denise Zellars
502-287-5222
Colorectal Cancer
Study of ctDNA Guided Therapy in Colorectal Cancer (BESPOKE)
Denise Zellars
502-287-5222
Lung Cancer
CliNIcal Utility of ManaGement of Patients witH CT and LDCT Identified Pulmonary Nodules UsinG the Percepta NasAL Swab ClassifiEr (NIGHTINGALE)
Denise Zellars
502-287-5222
Lung Cancer
A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients (TRITON)
Denise Zellars
502-287-5222
Prostate Cancer
High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers (VA-BAT)
Denise Zellars
502-287-5222
Infectious Disease
A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting (RECAP-20)
Coordinator
502-852-1585
Open Clinical Trials (ENROLLMENT CLOSED):
CONDITIONS
STUDY NAME
MORE
CONTACT
Diabetes Mellitus Type2
Semaglutide Cardiovascular Outcomes Trial in Patients With Type 2 Diabetes (SOUL)
Anne Marie Webb
502-287-5238
Overweight
Obesity
Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT)
Anne Marie Webb
502-287-5238
Cirrhosis
Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis (SACRED)
Jordan Ricks
502-287-5208
Lung Cancer
A Randomized, Open Label Phase 2/3 Study Comparing Cobolimab + Dostarlimab + Docetaxel To Dostarlimab + Docetaxel To Docetaxel Alone In Participants With Advanced Nonsmall Cell Lung Cancer Who Have Progressed On Prior Anti-PD-(L)1 Therapy And Chemotherapy (COSTAR Lung)
Denise Zellars
502-287-5222
Hepatocellular Carcinoma
A Randomized Phase 2 Trial of Atezolizumab and Bevacizumab in Combination With SRF388 or Placebo in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (SURFACE)
Denise Zellars
502-287-5222
COMING SOON! Clinical Trials (NOT YET ENROLLING):
CONDITIONS
STUDY NAME
MORE
CONTACT
Hypothyroidism
A Study to Assess the Safety and Efficacy ofOral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants (AVANTI)
Anne Marie Webb
502-287-5238
Colon Cancer
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer (AZUR-2)
Denise Zellars
502-287-5222
Lung Cancer
Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC (SKYSCRAPER-15)
Denise Zellars
502-287-5222
Lung Cancer
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer. (eVOLVE-Lung02)
Denise Zellars
502-287-5222
Lung Cancer
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening (PROACT-LUNG)
Denise Zellars
502-287-5222
Lung Cancer
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (Telimet)
Denise Zellars
502-287-5222
CLINICAL RESEARCH FOUNDATION INVESTIGATORS
Gastroenterology | Digestive & Liver Health
Endocrinology | Diabetes & Nutrition Care
Infectious Disease
Oncology | Hematology
Gastroenterology | Digestive & Liver Health
Gastroenterology | Digestive & Liver Health
Infectious Disease
Pulmonology
Oncology | Gastroenterology | Digestive & Liver Health
Cardiovascular Medicine
Gastroenterology | Digestive & Liver Health
Endocrinology | Diabetes & Nutrition Care
