Participate in Clinical Research for Veterans at the Clinical Research Foundation

From its inception, the U.S. Department of Veterans Affairs has deemed research an essential component to meet its mission: to provide the highest quality of health care possible to those who have served our country. Since 1946, clinical trials have been conducted at the VA that focus on alleviating the conditions prevalent among veterans. The goal of these trials has been to offer new drugs, devices and techniques to veterans to improve their health.

The principal investigators (PI) affiliated with the CRF are VA physicians who are committed to providing excellent care to their patients. Excellent care starts with an informed patient. Though you may receive many benefits from participating in clinical research as a subject–from gaining access to the latest pharmaceutical developments to the empowering feeling of giving back–there can be some risks, so if you are considering the possibility of participating please take time to evaluate for yourself and with your doctor if doing so is an appropriate option.

INTERESTED IN LEARNING MORE? CALL 502-287-5333

Current Clinical Trials:

Protocol Title	Investigator Name	Coordinator Name
A Phase III, Multicenter, Double-Blind, Placebo-Controlled, Treat-Through Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy with RO7790121 in Patients with Moderately to Severely Active Ulcerative Colitis	Gerald Dryden, MD, PhD	Anne Marie Webb
Phase II, Randomized, Double-Blind, Multicenter, Placebo-controlled study to evaluate the efficacy and safety of RO7795074 over 26 weeks in participants with Type 1 Diabetes Mellitus and Overweight or Obesity.	Sathya Krishnasamy, MD	Anne Marie Webb
A Phase 2/3 multicenter, double blinded, randomized, dose-conversion, active control study examining the efficacy and safety of Armour Thyroid compared to synthetic T4 for the treatment of adults with primary hypothyroidism.	Sathya Krishnasamy, MD	Anne Marie Webb
Colonoscopy vs. Fecal Immunochemical Test in Reducing Mortality from Colorectal Cancer	Dipendra Parajuli, MD	Anne Marie Webb
Liver and Systemic Effects of Toxic Exposures	Matthew Cave, MD	Jordan Ricks
ARC Therapy To Manage Symptomatic Blood Pressure Instability Secondary To Chronic Spinal Cord Injury	Ajmal Zemmar, MD	Anne Marie Webb
A Phase III, Two-Arm, Parallel, Randomized, Multi-Center, Open-Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer	Dharamvir Jain, MD Fred Hendler, MD	Dylan Pfost
Extensive recurrent small cell-lung cancer with biorepository; A biomarker directed trial of Temozolomide and Stenoparib in relapsed SCLC	Fred Hendler, MD	Dylan Pfost
A Phase 3, Multicenter, Double-blind, Randomized Controlled Study Evaluating the Efficacy and Safety of Pegloticase Administered by Subcutaneous Injection Compared With Pegloticase Administered by Intravenous Injection, Both Administered Concurrently With Methotrexate Weekly, in Participants With Uncontrolled Gout	Dave Armstrong, MD Gerald Dryden, MD, PhD	Anne Marie Webb
A Phase 1/2a Study of STM-416 Administered Intraoperatively to Patients Undergoing Transurethral Resection of Bladder Tumor (TURBT) for Recurrent High-Grade Papillary Bladder Cancer	Murali Ankem, MD	Anne Marie Webb
Biorepository for prostate cancer	Murali Ankem, MD Fred Hendler, MD	Dylan Pfost
Clinical utility of management of patients with CT and LDCT Identified Pulmonary Nodules using the Percepta nasal swab classifier (NIGHTINGALE) with familiarization	Umair Gauhar, MD Fred Hendler, MD	Dylan Pfost
A randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC.	Ashutosh Barve, MD	Anne Marie Webb
Pragmatic evaluation of events and benefits of lipid-lowering in older adults	Sathya Krishnasamy, MD	Jordan Ricks
A Phase 4 Study using a Test-Negative Design to Evaluate the Effectiveness of a 20-Valent Pneumococcal Conjugate Vaccine against Vaccine-Type Radiologically-Confirmed Community-Acquired Pneumonia in Adults over 65 Years of Age	Forest Arnold, DO	Gootee, Steven
A Phase III, Multicenter, Double-Blind, Placebo-Controlled, Treat-Through Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy with RO7790121 in Patients with Moderately to Severely Active Crohnâ€™s Disease	Gerald Dryden, MD, PhD	Anne Marie Webb
A Multicenter, Randomized, Double-blind, 2-Part Phase 2 Study to Evaluate the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC) Part 1: Placebo-Controlled, Dose-Ranging Study of GS-1427; Part 2: Active-Controlled, Combination Study Evaluating the Efficacy and Safety of GS-1427 in Combination With Ustekinumab versus GS-1427 or Ustekinumab monotherapy	Gerald Dryden, MD, PhD	Anne Marie Webb
Veterans with high levels of PFAS, treat with Colesevalam (not ursodiol as previously noted)	Matthew Cave, MD	Jordan Ricks
Bipolar androgen therapy for metastatic castration-resistant CA	Fred Hendler, MD	Anne Marie Webb